The core mission of our lab is to understand the inheritance and evolution of genome instability, especially in the context of cancer biology. By combining real-time evolutionary experiment and in silico genomic analysis, we approach this research theme via the following research lines.

  1. Constructing the genotype-phenotype map for genome instability via the lens of pangenome graph.
  2. Dissecting the inheritance and evolutionary mechanisms of genome instability via experimental evolution with cell models (mainly the budding and fission yeasts).
  3. Elucidating the evolutionary patterns and clinical implications of genome instability during cancer and cancer-associated virus evolution via the genomic analysis of clinical sequencing data.
  4. Developing novel sequencing technologies that targets genome instability via single-molecular sequencing.
  5. Building handy bioinformatics applications that quantitatively profile and visualize genome instability via comparative genomics.