Research

[In English]

The core mission of our lab is to understand the inheritance and evolution of genome instability, especially in the context of cancer biology. By combining real-time evolutionary experiment and in silico genomic analysis, we approach this research theme via the following research lines.

1. Charting the evolutionary landscape of mutation and recombination and their functional impacts via the lens of pangenome.
2. Dissecting the inheritance and evolutionary mechanisms of genome instability via experimental evolution with cell models.
3. Elucidating the evolutionary patterns and clinical implications of genome instability during cancer progression by applying genomic analysis on clinical samples.
4. Developing novel qualitative and quantitative profiling technologies that target genome instability via single-molecule sequencing.

[In Chinese]

我们课题组的核心使命是理解基因组不稳定性的遗传与演化规律，特别是其对肿瘤发生和进展的影响。在这个主题下，我们结合运用实验演化和基因组测序分析手段，从以下几个方面开展我们的研究。

1. 基于泛基因组解析基因组突变与重组的特征图谱和功能影响。
2. 基于实验演化体系研究基因组不稳定性的演化命运与调控机制。
3. 基于临床样本研究肿瘤基因组不稳定性的多维表征及临床意义。
4. 基于单分子测序开发靶向基因组不稳定性的定性定量新技术。